Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.
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چکیده
منابع مشابه
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.
Fenclozic acid (I.C.I. 54,450; 2-(p-chlorophenyl) thiazol-4-ylacetic acid; Myalex*) (Hepworth, Newbould, Platt, and Stacey, 1969) is one representative of a series of thiazolyl acetic acids which was active in the adjuvant-induced arthritis test in rats (Newbould, 1963) and which merited more detailed evaluation on this and other laboratory models (Newbould, 1969). Serum concentration studies i...
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Fenclozic acid (I.C.I. 54,450: Myalex) has recently been withdrawn from trial because of hepatotoxicity. In a published trial (Chalmers, Kellgren, and Platt, 1969), which suggests that it has some effect as an anti-inflammatory agent in rheumatoid arthritis, up to 400 mg. fenclozic acid were given daily for 10 days to 40 patients and compared with 3 6 g. aspirin daily. Two of these patients sho...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1969
ISSN: 0003-4967
DOI: 10.1136/ard.28.6.595